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Publications

2019

18. Fakhouri AS, Weist JL, Tomusko AR, Leight JL. High Throughput 3D Hydrogel Cell Encapsulation Assay for Measuring Matrix Metalloproteinase Activity. ASSAY and Drug Development Technologies, Apr 17(3): 100-115, 2019. (Link)

17. Fakhouri AS, Leight JL. Measuring Global Cellular Matrix Metalloproteinase and Metabolic Activity in 3D Hydrogels. Journal of Visualized Experiments, e59123, doi:10.3791/59123, 2019. (Link)

16. Jones CE, Hammer AM, Cho Y, Sizemore GM, Cukierman E, Yee LD, Ghadiali SN, Ostrowski MC, Leight JL. Stromal PTEN Regulates Extracellular Matrix Organization in the Mammary Gland. Neoplasia. Jan 21(1): 132–145, 2019. (Link)

2018

15. Deshmukh AA, Weist JL, Leight JL. Detection of Protease Activity by Fluorescent Peptide Zymography. Journal of Visualized Experiments, e58938, doi:10.3791/58938, 2018. (Link)

14. Deshmukh AA, Weist JL, Leight JL. Detection of proteolytic activity by covalent tethering of fluorogenic substrates in zymogram gels. Biotechniques. 64(5):203-210, 2018. (Link)

13. Barnhouse VR*, Weist JL*, Shukla VC, Ghadiali SN, Kniss DA, Leight JL.  Myoferlin Regulates Epithelial Cancer Cell Plasticity and Migration through Autocrine TGF-β1 Signaling. Oncotarget. 9 (27):19209–19222, 2018. (Link)

12. Shin DS, Tokuda EY, Leight JL, Miksch CE, Brown TE, Anseth KS. Synthesis of microgel sensors for spatial and temporal monitoring of protease activity. ACS Biomaterials Science and Engineering. 4(2):378-387, 2018. (Pubmed)

11. Shukla V, Barnhouse V, Ackerman WE, Summerfield TL, Powell HM,  Leight JL, Kniss DA, Ghadiali SN. Cellular Mechanics of Primary Human Cervical Fibroblasts: Influence of Progesterone and a Pro-Inflammatory Cytokine. Annals of Biomedical Engineering. Jan;46(1):197-207, 2018. (Link

2017

10. Leight JL*, Drain AP*, Weaver VW. Extracellular Matrix Remodeling and Stiffening Modulate Tumor Phenotype and Treatment Response. Annu Rev Cancer Biol.1:313-334, 2017.

2015

9. Leight JL*Tokuda EY*, Jones CE, Lin AJ, Anseth KS. Multifunctional bioscaffolds for 3D culture of melanoma cells reveal increased MMP activity and migration with BRAF kinase inhibition. Proc Natl Acad Sci U S A. 112(17):5366-71, 2015. (Pubmed

8. Sridhar BV, Brock JL, Silver JS, Leight JL, Randolph MA, Anseth KS. Development of a Cellularly Degradable PEG Hydrogel to Promote Articular Cartilage Extracellular Matrix Deposition. Adv Healthc Mater. 4(5):702-13, 2015. (Pubmed)

2014

7. Tokuda EY, Leight JL, and Anseth KS. Modulation of matrix elasticity with PEG hydrogels to study melanoma drug responsiveness. Biomaterials. 35(14):4310-8, 2014. (Pubmed)

2013

6. Leight JL, Alge DA, Maier AJ, and Anseth KS. Direct measurement of matrix metalloproteinase activity in 3D cellular microenvironments using a fluorogenic peptide substrate. Biomaterials. 34(30):7344-52, 2013. (Pubmed)

2012

5. Leight JL*, Liu WL*, Chaturvedi RR, Chen S, Yang MT, Raghavan S, and Chen CS. Manipulation of 3D cluster size and geometry by release from 2D micropatterns. Cellular and Molecular Bioengineering. 5(3):299-306, 2012. (Pubmed)

4. Leight JL, Wozniak MA, Chen S, Lynch ML, and Chen CS. Matrix rigidity regulates a switch between TGF-β1-induced apoptosis and epithelial-mesenchymal transition.Molecular Biology of the Cell. 23(5):781-91, 2012. (PubmedHighlighted by Faculty of 1000, March 2012

2009

3. Gehler S, Baldassarre M, Lad Y, Leight JL, Wozniak MA, Riching KM, Eliceiri KW, Weaver VM, Calderwood DA, and Keely PJ. Filamin A-{beta}1 Integrin Complex Tunes Epithelial Cell Response to Matrix Tension.  Molecular Biology of the Cell. 20(14): p3224-3238, 2009. (Pubmed)

2007

2. Johnson KR, Leight JL, and Weaver VM. Demystifying the Effects of a Three-Dimensional Microenvironment in Tissue Morphogenesis. Methods in Cell Biology. 83: p539-575, 2007. (Pubmed)

1. Janmey PA, McCormick ME, Rammensee S, Leight JL, Georges PC, and Mackintosh FC. Negative normal stress in semiflexible biopolymer gels. Nature Materials. 6(1):p48-51, 2007. (Pubmed)

Bold highlights Leight lab members

*both authors contributed equally to this work